I’m interested in evaluating pediatric outcomes for the HowOften study and wondered if anyone would like to work with me on them. We are planning in the future to develop a pediatric study so this would be a nice way to evaluate the phenotypes and to do some feasibility in advance of development of research questions.
The following phenotypes are of interest:
Otitis media
motor vehicle accidents
asthma
burns - Skin Burns
Firearm Accidents
Drug Overdose and Poisoning
Suffocation
Drowning
Cystic Fibrosis
Down Syndrome
Autism
Atopic Dermatitis
We have literature reviews for asthma, autism, and atopic dermatitis and I have boiler plate clinical descriptions which can be shared with anyone interested. If you are a clinician, your expertise would be helpful in authoring clinical descriptions for these phenotypes. If you would like to pitch in on evaluating the phenotype algorithms, we could do that together.
Also, for cystic fibrosis, Down syndrome (and probably also autism and atopic dermatitis) there is no “before” incidence. Do you care? What do you intend to compare it to?
What about childhood infections and cancers? (I know you are looking for people who don’t add more, but actually sign up for doing some )
Christian_Reich I found a few of the phenotypes listed above in the Ohdsi phenotype library so for now those will suffice for the HowOften study. I’d be interested in background rates of these as a start. Yes the additional phenotypes you suggest would be helpful but alas I’ve been working on a few for the HowOften study and will post them now. Stay tuned.
In follow up to this post this maybe useful organizationally.
Here is the target and outcome cohorts and age strata:
Target: people who were observed on 1 January 2017, 1 January 2018, or 1 January 2019 and were observed for at least 365 days before this observation date (identical to the target used in the covidaesi OHDSI study)
Outcomes and cohort ids:
attention deficit hyperactivity disorder 134
chronic lymphocytic leukemia 470
Guttate psoriasis 667
suicide 690
otitis media 533
motor vehicle accidents 753
asthma 521
skin burns TBD
firearm accidents 752
cystic fibrosis TBD
down syndrome 754
autism 591
atopic dermatitis 466
Age strata - those defined in the HowOften protocol
These phenotypes were selected by referencing this publication: https://www.nejm.org/doi/full/10.1056/NEJMsr1804754 although in this publication the outcome is death which is not being proposed here. We have added a few phenotypes of interest but acknowledge that it is not an exhaustive list of phenotypes of interest in pediatrics. Tagging and thanking @Azza_Shoaibi as she has been my phenotype collaborator.
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