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Mapping drug identifiers (NDC or RxNorm) to on-label drug indications using ICD10 codes

(Ilya Katz) #1

Does a mapping between drug identifiers like NDC or RxNorm to valid drug indications, per the label, using ICD10 codes or other disease/diagnosis descriptors exist. I know that there are some commercial data vendors that have attempted this but wasn’t sure if there was anything in the public domain?

Build Drug-Medical Condition Relationship
(Christian Reich) #2


There is a link from RxNorm to FDB indications, and from there to SNOMED. And there was a similar link from RxNorm to NDF-RT indication, and from there to SNOMED. But NDF-RT is no longer available, and the replacement MED-RT we have not put in, and we may never do that.

This idea sounds nice, but it actually doesn’t work very well. These indications are more like hints. You can display them on an e-ordering system when the physician is browsing products. But for our purposes the idea that you somehow can get all the ICD-10 codes that represent the indication and then find the patient with the indication - pretty much a fallacy. First, most indications are wishy-washy, and not strict ICD-10 or SNOMED material. Image things like “general anxiety”, “difficulty sleeping through”, “fever”, “papulo-vesicular skin lesions”. Second, the links would have to be very broad (and then collecting too many unrelated Conditions, or narrow (missing a lot). In other words the sensitivity/specificity curve is not very favorable.

I would stay away from that. What’s your use case?

Drug to disease - Cross domain mapping