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Favorite OHDSI Papers Of 2019


(Maura Beaton) #1

With 2019 concluding, we’d love to create a thread of the community’s favorite or most inspiring OHDSI papers from the past 12 months.

Was there a paper that used OHDSI tools and standards particularly inspiring to you? Please share them here, so we can all take a look back at some of community highlights and perhaps gain some early inspiration for 2020.


Weekly OHDSI Digest - 6Jan2020
Weekly OHDSI Digest - 27Jan2020
Weekly OHDSI Digest - 13Jan2020
(Ella) #2

Presented at the AMIA symposium in SF - ‘SALT-C: Standardization Algorithm for Categorical Laboratory Tests for Clinical Big Data Research’ by Kim, Shin, et. al.


(Vojtech Huser) #3

SALT-C url would be https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6740165/


(Vojtech Huser) #4

https://www.researchgate.net/publication/336776100_Comparison_of_First-Line_Dual_Combination_Treatments_in_Hypertension_Real-World_Evidence_from_Multinational_Heterogeneous_Cohorts

repo at https://github.com/OHDSI/StudyProtocolSandbox/tree/master/HypertensionCombination


(Maura Beaton) #5

There’s still time to let us know your favorite OHDSI community publications from 2019.

Was there a paper that used OHDSI tools and standards that was particularly inspiring to you? Please share them here, so we can all take a look back at some of community highlights and perhaps gain some early inspiration for 2020.


(Theresa Burkard) #6

https://www.thelancet.com/journals/lanrhe/article/PIIS2665-9913(19)30075-X/fulltext


OHDSI Community Call 28Jan2020
(Christophe Lambert) #7

Our group published 3 papers in the mental health domain that appeared online in 2019 (despite some 2020 publication dates) that made heavy use of the Common Data Model, all open access:

  • Kumar P, Nestsiarovich A, Nelson SJ, Kerner B, Perkins DJ, Lambert CG. Imputation and characterization of uncoded self-harm in major mental illness using machine learning. J Am Med Inform Assoc. 2020 Jan 1;27(1):136–146. PMID: 31651956 https://doi.org/10.1093/jamia/ocz173

  • Nestsiarovich A, Kerner B, Mazurie AJ, Cannon DC, Hurwitz NG, Zhu Y, Nelson SJ, Oprea TI, Crisanti AS, Tohen M, Perkins DJ, Lambert CG. Diabetes mellitus risk for 102 drugs and drug combinations used in patients with bipolar disorder. Psychoneuroendocrinology. 2020 Feb;112:104511. PMID: 31744781 https://doi.org/10.1016/j.psyneuen.2019.104511

  • Nestsiarovich A, Kerner B, Mazurie AJ, Cannon DC, Hurwitz NG, Zhu Y, Nelson SJ, Oprea TI, Unruh ML, Crisanti AS, Tohen M, Perkins DJ, Lambert CG. Comparison of 71 bipolar disorder pharmacotherapies for kidney disorder risk: The potential hazards of polypharmacy. J Affect Disord. 2019 Jun 1;252:201–211. PMID: 30986735 https://doi.org/10.1016/j.jad.2019.04.009

We had the opportunity to present the work of the first article on self-harm imputation with the JAMIA Mental Health Informatics Working Group, with a ~30-minute video here: https://zoom.us/rec/share/u8IsAZer01JLbrPj-VvSfqp8Hof-X6a8gCFIq_QPy0bxOXca1_newS5xHUTvciz5


(Vojtech Huser) #8

Drugs in Peds

https://bmjopen.bmj.com/content/10/1/e032426.long
github: https://github.com/OHDSI/StudyProtocols/tree/master/DrugsInPeds
protocol: https://github.com/OHDSI/StudyProtocols/raw/master/DrugsInPeds/extras/OHDSI%20Drug%20Utilization%20in%20Children%20Protocol.docx


(ruth etzioni) #9

Hi Christophe, I am very interested in your work in the mental health domain and was wondering if anyone is studying increases in the use of antipsychotics and medications for bipolar disorder after the DSM-V changed the definition of bipolar disorder to include patients who had had a manic reaction to SSRI’s including sirtralene. I sense that patients identified as having bipolar disorder and prescribed dangerous medications for this disorder have skyrocketed with major adverse effects. Do you think such an investigation would be feasible?
thank you!


(Kristin Kostka, MPH) #10

Hi @retzioni! There is a Psychiatry WG that formed last fall. @Dymshyts is leading. We can add you to the call series. Next meeting is 6 Feb. Our wiki page is: https://www.ohdsi.org/web/wiki/doku.php?id=projects:workgroups:psychiatry

We have OHDSI investigators at Ajou (@SCYou and team) working to standardize this into the OMOP vocabularies.

We’d love to have your team involved too, @Christophe_Lambert! This research is so valuable for understanding this vulnerable population. Thanks for sharing your great work!


(Christophe Lambert) #11

Hi Ruth,

We saw in our data that about 40% of patients ultimately diagnosed with bipolar disorder were first diagnosed with major depressive disorder. Particularly with bipolar II, patients may see hypomania as a beam of sunshine amidst a cloudy backdrop of depression, and are perhaps more likely to seek treatment for the latter when those are the presenting symptoms.

Antidepressants are commonly prescribed for patients with bipolar disorder, with risk of manic switch being a highly studied question, where there is no one-size-fits-all answer.

Jenna Reps and I are preparing an OHDSI network study on predicting the risk of patients first diagnosed with depression being subsequently diagnosed with bipolar disorder that we will talk about on the February 25 OHDSI Community call.

Christophe


(ruth etzioni) #12

Fantastic - I will try and joint that call. Would it be possible and of interest for you and Jenna to compare this for the years before versus after the introduction of the DSM-V? I bet after the DSM-V more patients first diagnosed with depression are receiving a diagnosis of bipolar disorder. This can be devastating as bipolar drugs which bring patients down from mania are piled on just as they are withdrawing from the antidepressants that caused the mania in the first place.
Thanks for responding to my message


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