Weekly OHDSI Digest - October 27, 2025

WEEKLY COMMUNITY CALL MEETING

Please join us Tuesday, Oct. 28 (11 am ET) to meet our 2025 Titan Award winners. Nominated and awarded by fellow community members, these collaborators did exceptional work to further OHDSI’s mission this year. You will learn about their journeys and work this Tuesday! The 2025 Titan Award winners are:

Data Standards: Polina Talapova

Methodological Research: Joel Swerdel

Open-Source Development: Jared Houghtaling, Aniek Markus, Maarten van Kessel

Clinical Applications: DARWIN EU Team

Community Collaboration: Liesbet Peeters, Ilse Vermeulen, Lotte Geys

Community Support: Agnes Kiragga

Community Leadership: Greg Klebanov

Everybody is invited. If you do not have a calendar invite, please use this link to join the meeting. All recordings from these weekly calls are available within our Teams environment and will be posted on both our YouTube page and our OHDSI.org Community Calls page.

WEEKLY WORKING GROUP MEETINGS

Upcoming Workgroup Calls – OHDSI

OHDSI SHOUTOUTS

Congratulations to the team of Kye Hwa Lee, Sujung Jang, Grace Juyun Kim, Sukyoung Park, Doeun Kim, Oh Jin Kwon, Jae-Ho Lee, and Young-Hak Kim on the recent publication of Large Language Models for Automating Clinical Trial Criteria Conversion to Observational Medical Outcomes Partnership Common Data Model Queries: Validation and Evaluation Study in JMIR Medical Informatics.

• Congratulations to the team of Lucía Bellas, Martí Català, Edward Burn, Yuchen Guo, Mike Du, Katia Verhamme, Egil Fridgeirsson, Talita Duarte-Salles, Tommi Kauko, Eeva Kronqvist, James T. Brash, Sarah Seager, Daniel Prieto-Alhambra, Annika M. Jödicke, and Albert Prats-Uribe on the recent publication of Secular Trends in the Use of Valproate-Containing Medicines in Women of Childbearing Age in Europe: A Multinational DARWIN EU Network Study in Pharmacoepidemiology and Drug Safety.

• Congratulations to our 2025 Collaborator Showcase Best Community Contribution winners, as voted on at the Global Symposium!

Data Standards: OMOP Waveform Extension: A Schema for Integrating Physiological Signals and Derived Features into the OMOP CDM (Jared Houghtaling, Polina Talapova, Brian Gow, Manlik Kwong, Andrew J King, Benjamin Moody, Mike Kriley, Tom Pollard, Andrew E Williams)

Methodological Research: LATTE: A One-shot Lossless Algorithm for Federated Target Trial Emulation with Application to Alzheimer’s Disease and Related Dementia Drug Repurposing Using Decentralized Data(Lu Li, Qiong Wu, Yiwen Lu, Kyra S. O’Brien, Bingyu Zhang, Ting Zhou, Jiayi Tong, Dazheng Zhang, Yuqing Lei, Huilin Tang, Yun Lu, David Asch, Yong Chen)

Open-Source Development: Automated OMOP Concept Mapping Using Multi-Agent Large Language Models and Graph-Enhanced Semantic Retrieval (Adil Ahmed, Selvin Soby, Boudewijn Aasman, Parsa Mirhaji)

Clinical Applications: Heterogeneity of Treatment Effects Across Nine Glucose-Lowering Drug Classes in Type 2 Diabetes: Extension of the LEGEND-T2DM Network Study (Hsin Yi “Cindy” Chen, Thomas Falconer, Anna Ostropolets, Tara V. Anand, Xinzhuo Jiang, David Dávila-García, Linying Zhang, Ruochong Fan, Hannah Morgan-Cooper, George Hripcsak)

Community: Building the OHDSI Evidence Network – A Global, Open, Federated Collaboration(Clair Blacketer, Haeun Lee, Benjamin Martijn, Evanette Burrows, Patricia Mabry, Deran McKeen, Sam Patnoe, Ben Gerber, Pantelis Natsiavas, Aamirah Vadsariya, Hanieh Razzaghi, Paul Nagy)

OHDSI UPDATES

There is a new tutorials homepage on OHDSI.org that hosts all tutorials from past Global/US Symposia, as well as tutorials from the SOS Challenge. Future tutorials will also be added here.

• Registration is now open for the 2026 Summer School in Observational Health Data Science & Informatics, AI, and Real World Evidence, which will be held June 22-26 at the Columbia University Department of Biomedical Informatics. Now in its second-year, the Columbia OHDSI Summer School provides health professionals, researchers, and industry practitioners with an immersive, hands-on training to working with real-world health data and generating real-world evidence (RWE). Participants will explore the types of healthcare data captured during routine clinical care—such as electronic health records and administrative claims—and learn how to standardize these data using the OMOP Common Data Model to support collaborative, distributed research as part of a data network.

• A scholarship honoring the late Jamie Weaver has been created at the University of Oxford, and applications are now being accepted. This 3-year PhD funded studentship will focus on ‘Improving the quality of real world evidence by measuring and minimising outcome misclassification using the OMOP common data model and large multinational health data,’ research that Weaver was leading during his time as a PhD trainee at Oxford. More information and application details are available here.

OHDSI Social Showcase

• Research from the 2025 Europe Collaborator Showcase is being shared daily on OHDSI’s LinkedIn, Twitter/X, Instagram and Bluesky social channels as part of the #OHDSISocialShowcase. Below are posters (with study leads) that are featured this week:

Monday — Data quality framework for cohort discovery: Insights from the design of the global WAYFIND-R oncology real-world data research platform (Tom Stone)

Tuesday — Development of the HEARTwise ML framework to predict patient

Deterioration (Frederick De Baene)

Wednesday — DARWIN EU® - Latest trends in use of Attention-Deficit Hyperactivity Disorder (ADHD) Medications among children and adult in five European countries (Xintong Li)

Thursday — DARWIN EU® - Prescription pattern of STOPP section K criteria medication in older adults with and without recurrent falls (Akram Mendez)

Friday — DARWIN EU® - Chondrosarcoma: patient demographics, treatments, and survival in the period 2010-2023 (Anton Barchuk)

UPCOMING OHDSI EVENTS

The first-ever 2025 OHDSI Africa Symposium will be held Nov. 10-12 in Kampala, Uganda, and registration is open. A tentative agenda has been posted on the event homepage.

• The 2025 OHDSI Asia-Pacific Symposium will be held Dec. 6-7 in Shanghai, China. Registration is open, and agenda details will be shared when available.

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