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RxNorm Extension flaw - drug cohorts AFFECTED


(Alexander Davydov) #1

There’s a bug in RxNorm Extension that was reported here.

The problem is missing links/attributes in the RxNorm Extension Standard concepts that are being lost (and not replaced by the RxNorm equivalents) during the process of RxNorm Extension to RxNorm ingredient replacement.

It affects cohorts since some of the Standard Drug concepts are not linked to their Ingredients in the CONCEPT_ANCESTOR table. And the cohorts built out of the ingredients (+ their descendants) may miss some concepts.

As for v20201222, the issue affects around 1% of concepts:

The full list of affected concepts:

Statistics:

list (click to expand)
vocabulary_id concept_class_id count
RxNorm Extension Branded Drug 1207
RxNorm Extension Branded Drug Box 1653
RxNorm Extension Branded Drug Comp 1647
RxNorm Extension Branded Drug Form 2343
RxNorm Extension Branded Pack 1
RxNorm Extension Clinical Drug 424
RxNorm Extension Clinical Drug Box 1393
RxNorm Extension Clinical Drug Comp 431
RxNorm Extension Clinical Drug Form 136
RxNorm Extension Clinical Pack 1
RxNorm Extension Marketed Product 3889
RxNorm Extension Quant Branded Box 544
RxNorm Extension Quant Branded Drug 619
RxNorm Extension Quant Clinical Box 700
RxNorm Extension Quant Clinical Drug 723

While we’ll be fixing this, an additional review/search among the affected concepts is needed. Once you found the concept of interest in the list, add them manually to your cohorts.


(Tsonko Tsonkov) #2

Dear Alexander,

Thank you for further looking that issue. Finding which exact drugs are influenced by it would be of great help.

Best
Tsonko


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