We also have Don’s Perl version doing the iterations, if that’s any help.
From: Patrick Ryan [mailto:firstname.lastname@example.org] On Behalf Of Patrick Ryan
Sent: Monday, November 24, 2014 6:22 PM
Subject: [OHDSI Forums] [Implementers] Populating *_era tables?
Hi Ryan: There's been several implementations of era builders. Originally, OMOP provided a tool called GERALD that provided SAS and Oracle SQL solutions. The code is available at: http://omop.org/cdm
I've done it myself in TSQL script with cursors, but found it wasn't super fast with big data, so wouldn't recommend that approach. Chris came up with a very clever approach to building eras in pure SQL, here's a snippet below for drug era, assuming you're working with OMOP CDM v4 in SQL Server and have pharmacy claims with days supply to infer end dates for each exposure record:
with cteDrugTarget (DRUG_EXPOSURE_ID, PERSON_ID, DRUG_CONCEPT_ID, DRUG_EXPOSURE_START_DATE, DRUG_EXPOSURE_END_DATE, DRUG_TYPE_CONCEPT_ID, REFILLS, QUANTITY, DAYS_SUPPLY, RowNum) as(-- Normalize DRUG_EXPOSURE_END_DATE to either the existing drug exposure end date, or add days supply, or add 1 day to the start dateselect d.DRUG_EXPOSURE_ID, d. PERSON_ID, c1.concept_id as DRUG_CONCEPT_ID, d.DRUG_EXPOSURE_START_DATE, COALESCE(d.DRUG_EXPOSURE_END_DATE, DATEADD(day,d.DAYS_SUPPLY,d.DRUG_EXPOSURE_START_DATE), DATEADD(day,1,DRUG_EXPOSURE_START_DATE)) as DRUG_EXPOSURE_END_DATE, d.DRUG_TYPE_CONCEPT_ID, d.REFILLS, d.QUANTITY, d.DAYS_SUPPLY,ROW_NUMBER() OVER (PARTITION BY d.PERSON_ID, c1.concept_id ORDER BY d.DRUG_EXPOSURE_START_DATE) as RowNumFROM CDM4_SIM.dbo.DRUG_EXPOSURE dinner join CONCEPT_ANCESTOR ca on d.DRUG_CONCEPT_ID = ca.DESCENDANT_CONCEPT_IDinner join concept c1 on ca.ANCESTOR_CONCEPT_ID = c1.concept_id and c1.VOCABULARY_ID = 8 and c1.concept_level = 2),cteEndDates (PERSON_ID, END_DATE) as(select PERSON_ID, DATEADD(day,-30,EVENT_DATE) as END_DATE -- unpad the end dateFROM(select PERSON_ID, DRUG_CONCEPT_ID, EVENT_DATE, EVENT_TYPE, MAX(START_ORDINAL) OVER (PARTITION BY PERSON_ID, DRUG_CONCEPT_ID ORDER BY EVENT_DATE, EVENT_TYPE ROWS UNBOUNDED PRECEDING) as START_ORDINAL, -- this pulls the current START down from the prior rows so that the NULLs from the END DATES will contain a value we can compare with ROW_NUMBER() OVER (PARTITION BY PERSON_ID, DRUG_CONCEPT_ID ORDER BY EVENT_DATE, EVENT_TYPE) AS OVERALL_ORD -- this re-numbers the inner UNION so all rows are numbered ordered by the event datefrom(-- select the start dates, assigning a row number to eachSelect PERSON_ID, DRUG_CONCEPT_ID, DRUG_EXPOSURE_START_DATE AS EVENT_DATE, 1 as EVENT_TYPE, ROW_NUMBER() OVER (PARTITION BY PERSON_ID, DRUG_CONCEPT_ID ORDER BY DRUG_EXPOSURE_START_DATE) as START_ORDINALfrom cteDrugTargetUNION ALL-- pad the end dates by 30 to allow a grace period f or overlapping ranges.select PERSON_ID, DRUG_CONCEPT_ID, DATEADD(day,30,DRUG_EXPOSURE_END_DATE), -1 as EVENT_TYPE, NULLFROM cteDrugTarget) RAWDATA) EWHERE (2 * E.START_ORDINAL) - E.OVERALL_ORD = 0),cteRawData as(select d.DRUG_EXPOSURE_ID, d.PERSON_ID, d.DRUG_CONCEPT_ID,d.DRUG_EXPOSURE_START_DATE, d.DRUG_EXPOSURE_END_DATE, MIN(e.END_DATE) as ERA_END_DATE,d.DRUG_TYPE_CONCEPT_ID, d.REFILLS, d.QUANTITY, d.DAYS_SUPPLY, d.RowNum,ROW_NUMBER() OVER (PARTITION BY d.PERSON_ID, MIN(e.END_DATE) ORDER BY d.PERSON_ID, d.DRUG_CONCEPT_ID, d.DRUG_EXPOSURE_START_DATE) as EraRowNumFROM cteDrugTarget dJOIN cteEndDates e on d.PERSON_ID = e.PERSON_ID and e.END_DATE >= d.DRUG_EXPOSURE_START_DATEGROUP BY d.DRUG_EXPOSURE_ID, d.PERSON_ID, d.DRUG_CONCEPT_ID, d.DRUG_EXPOSURE_START_DATE, d.DRUG_EXPOSURE_END_DATE, d.DRUG_TYPE_CONCEPT_ID, d.REFILLS, d.QUANTITY, d.DAYS_SUPPLY, d.RowNum) select row_number() over (order by person_id asc) as DRUG_ERA_ID,r.PERSON_ID, r.DRUG_EXPOSURE_START_DATE as DRUG_ERA_START_DAT E, r.ERA_END_DATE as DRUG_ERA_END_DATE, 38000182 as DRUG_TYPE_CONCEPT_ID,r.DRUG_CONCEPT_ID,1 as DRUG_EXPOSURE_COUNTinto CDM4_SIM.dbo.DRUG_ERA from cteRawData r where r.EraRowNum = 1 order by r.PERSON_ID, r.DRUG_CONCEPT_ID, r.DRUG_EXPOSURE_START_DATE;
Any of these approaches should work for OMOP CDMv4. For OMOP CDMv5, I'm planning to write up a SQL script approach loosely based on Chris' implementation that I think should work well for drug_era, dose_era, and condition_era, that we can run through SqlRender to make it work for Oracle, SQL Server, and PostgresQL. I need to do a bit more testing on that first though so I don't create too much re-work for those who'd like to implement it.
Of course, there's lots of ways to skin this cat, I'd be quite keen to hear how others have tackled this problem.
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