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Phenotype Submission - VZV Anterior Uveitis

Attach cohort definitions: Because I am a new user, it will not let me upload a file into the submission. I have added the link to our cohort definition at the bottom of this post.

Cohort Definition Names: VZV Anterior Uveitis (SUN), VZV Anterior Uveitis (SUN, sensitivity analysis)

Contributor names:

Contributor ORCID Organization
Edward Lee N/A Roski Eye Institute, Keck School of Medicine, USC
Kiana Tavakoli 0000-0003-1883-9018 Shiley Eye Institute, University of California San Diego
Rupesh Agrawal 0000-0002-6662-5850 National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore
William Rojas Carabali 0000-0002-9976-8989 Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore
Karen Armbrust 0000-0001-9381-4756 Minneapolis VA Health Care System, University of Minnesota
Kareem Moussa 0000-0001-9110-9594 Department of Ophthalmology & Vision Science, University of California, Davis
Jessica Shantha 0000-0002-4449-8598 F.I. Proctor Foundation, University of California, San Francisco
Edmund Tsui 0000-0001-7532-9191 UCLA Stein Eye Institute, David Geffen School of Medicine at UCLA
Brian Toy 0000-0002-9612-5697 Roski Eye Institute, Keck School of Medicine, USC

Clinical description: Computable definition of SUN classification criteria for VZV anterior uveitis. This phenotype is of patients with a diagnosis or clinical findings of anterior uveitis that is consistent with an etiology of varicella zoster virus (VZV) infection. This phenotype operationalizes the definition published by the SUN workgroup (Classification Criteria for Varicella Zoster Virus Anterior Uveitis - PubMed (nih.gov))

Logic description:


  1. Evidence of anterior uveitis

    a. anterior chamber cells
    b. if anterior vitreous cells are present, severity is less than anterior chamber inflammation
    c. no evidence of retinitis


  1. Unilateral uveitis (unless there is a positive aqueous PCR for varicella zoster virus)


  1. Evidence of varicella zoster virus infection in the eye

    a. aqueous humor PCR positive for varicella zoster virus OR
    b. sectoral iris atrophy in a patient ≥ 60 years of age OR
    c. concurrent or recent dermatomal Herpes zoster
    d. included in sensitivity analysis phenotype diagnosis of recent VZV infection


  1. Positive serology for syphilis using a treponemal test
  2. Evidence of sarcoidosis (either bilateral hilar adenopathy on chest imaging or tissue biopsy demonstrating non-caseating granulomata)
  3. Aqueous specimen PCR positive for cytomegalovirus or herpes simplex virus

Final Logic Description used to construct phenotype on ATLAS:

Recommended Study applications: target

Submitted cohort definition: ATLAS: Cohort Definitions (ohdsi.org)

Submitted cohort definition: ATLAS: Cohort Definitions (ohdsi.org; sensitivity analysis)