Attach cohort definitions: Because I am a new user, it will not let me upload a file into the submission. I have added the link to our cohort definition at the bottom of this post.
Cohort Definition Names: VZV Anterior Uveitis (SUN), VZV Anterior Uveitis (SUN, sensitivity analysis)
Contributor names:
| Contributor | ORCID | Organization | |||
|---|---|---|---|---|---|
| Edward Lee | N/A | Roski Eye Institute, Keck School of Medicine, USC | |||
| Kiana Tavakoli | 0000-0003-1883-9018 | Shiley Eye Institute, University of California San Diego | |||
| Rupesh Agrawal | 0000-0002-6662-5850 | National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore | |||
| William Rojas Carabali | 0000-0002-9976-8989 | Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore | |||
| Karen Armbrust | 0000-0001-9381-4756 | Minneapolis VA Health Care System, University of Minnesota | |||
| Kareem Moussa | 0000-0001-9110-9594 | Department of Ophthalmology & Vision Science, University of California, Davis | |||
| Jessica Shantha | 0000-0002-4449-8598 | F.I. Proctor Foundation, University of California, San Francisco | |||
| Edmund Tsui | 0000-0001-7532-9191 | UCLA Stein Eye Institute, David Geffen School of Medicine at UCLA | |||
| Brian Toy | 0000-0002-9612-5697 | Roski Eye Institute, Keck School of Medicine, USC |
Clinical description: Computable definition of SUN classification criteria for VZV anterior uveitis. This phenotype is of patients with a diagnosis or clinical findings of anterior uveitis that is consistent with an etiology of varicella zoster virus (VZV) infection. This phenotype operationalizes the definition published by the SUN workgroup (Classification Criteria for Varicella Zoster Virus Anterior Uveitis - PubMed (nih.gov))
Logic description:
Inclusion
-
Evidence of anterior uveitis
a. anterior chamber cells
b. if anterior vitreous cells are present, severity is less than anterior chamber inflammation
c. no evidence of retinitis
AND
- Unilateral uveitis (unless there is a positive aqueous PCR for varicella zoster virus)
AND
-
Evidence of varicella zoster virus infection in the eye
a. aqueous humor PCR positive for varicella zoster virus OR
b. sectoral iris atrophy in a patient ≥ 60 years of age OR
c. concurrent or recent dermatomal Herpes zoster
d. included in sensitivity analysis phenotype diagnosis of recent VZV infection
Exclusions
- Positive serology for syphilis using a treponemal test
- Evidence of sarcoidosis (either bilateral hilar adenopathy on chest imaging or tissue biopsy demonstrating non-caseating granulomata)
- Aqueous specimen PCR positive for cytomegalovirus or herpes simplex virus
Final Logic Description used to construct phenotype on ATLAS:
Recommended Study applications: target
Submitted cohort definition: ATLAS: Cohort Definitions (ohdsi.org)
Submitted cohort definition: ATLAS: Cohort Definitions (ohdsi.org; sensitivity analysis)