Cohort Definition Name : Earliest event of Type 2 Diabetes Mellitus (DM), with no type 1 or secondary DM
Contributor name : Patrick Ryan,
Contributor OrcId :
Logic Description : Earliest event of Type 2 Diabetes Mellitus (DM), indexed on diagnosis or Blood glucose lowering drugs excluding insulin or high Hemoglobin A1c (limited to treatments or measurement that are followed with Type 2 DM diagnosis within 365 days) excluding persons with Type 1 DM or secondary diabetes mellitus in the all time prior including index date
Recommended study application : target
Assertion statement : This cohort definition was executed on at least one real person-level observational health data source and resulted in a cohort with at least 1 person.
Target Clinical Description : The epidemiology and disease natural history of T2DM has been extensively characterized in the literature. In brief, T2DM is a metabolic disorder where high levels of blood sugar occur that accounts for nearly 90% of diabetic cases. The condition is often resulted from insulin resistance and/or lack of insulin.
Evaluation conclusion : We developed three prevalent cohort definitions for type 2 diabetes mellitus (T2DM) using concept sets which incorporated all those found from the literature review and from the analysis of PHOEBE and orphan concepts in cohort diagnostics. We performed the evaluation across a network of claim data sources and 1 EHR US data source. The data sources are: IBM® MarketScan® Commercial Database (CCAE), Optum’s longitudinal EHR repository (Optum EHR), Optum’s Clinformatics® Data Mart (DOD), IBM® MarketScan® Multi-State Medicaid Database (MDCD), IBM® MarketScan® Medicare Supplemental Database (MDCR), Japan Claims Database (JMDC), Clinical Practice Research Datalink (CPRD) , IQVIA® Australia Longitudinal Patient Data (LPD) database (Australia), IQVIA® Disease Analyzer (DA) France database (France), QVIA® Disease Analyzer (DA) Germany database (Germany), IQVIA® Adjudicated Health Plan Claims Data (formerly PharMetrics Plus) - US database (PharMetrics), IQVIA® Ambulatory EMR (EMR). The algorithms retrieve subjects from all 11 databases tested. The sensitivity ranged from 06 to 0.82 and PPV ranged from 0.98 to 0.99
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Imported to the OHDSI Phenotype Library. It may be expected to be found with id = 1032 in the next release. Thank you