The OHDSI Phenotype library has 29 cohort definitions that are either symptoms or signs – all in pending peer review status. These cohort definitions need to go through the phenotype submission and evaluation (peer review) cycle.
Because these are presentations of disease, and not a disease by itself itself - I think, they don’t easily fit the process we have been following recently. So, i think a single post like this may be sufficient to discuss these phenotypes.
I will try to provide a commentary on what I see in Cohort diagnostics. It would be great if other clinicians in the forum have a look at them and provide a commentary of their opinions.
These cohort definitions are useful for many reasons:
They may be used as feature cohorts. e.g. when characterizing a disease such as Myocardial Infarction - it is more informative to use a cohort definition for nausea or vomiting, chest pain - instead of individual codes. Feature/covariate cohorts are handled by OHDSI software like https://github.com/OHDSI/FeatureExtraction/pull/167 it may also be used in propensity score calculation.
Outcome cohorts: it may be used in comparative effectiveness or safety studies were the outcome maybe such signs or symptoms.
|3||Cough or Sputum|
|7||Headache or Headache disorder|
|8||Anosmia OR Hyposmia OR Dysgeusia|
|10||Nausea or Vomiting|
|11||Malaise or fatigue|
|12||Rhinitis or common cold|
|13||Myalgia (not explained by injury, ischemia or systemic inflammation)|
|64||Flu-like symptoms fever, cough, malaise, fatigue, dyspnea, myalgia|
|189||Right Upper Quadrant Pain|
|191||Fatigue, Malaise, Lethargy, Anorexia|
|193||Jaundice or Itching|
|194||Encephalopathy or its presentations|