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Phenotype Submission - Right Heart Failure

Cohort Definition Name: “Right Heart Failure”
Contributor name: Joel N. Swerdel
Contributor OrcId: 0000-0001-9491-2737
Logic Description: First occurrence of Right Heart Failure.
Recommended study application: outcome, indication
Assertion statement: This cohort definition was executed on at least one real person-level observational health data source and resulted in a cohort with at least 1 person.
Submitted cohort definition:
rhf.txt (1.3 KB)

Target Clinical Description

Right heart failure occurs when the right side of the heart is unable to effectively pump blood to the lungs for oxygenation. It is often caused by left heart failure, lung diseases (such as chronic obstructive pulmonary disease), or conditions that increase pulmonary vascular resistance. Right heart failure leads to fluid accumulation in the body, particularly in the legs, ankles, and abdomen. Common symptoms include swelling, fatigue, shortness of breath, and a feeling of fullness in the abdomen. Proper management aims to address the underlying cause, improve heart function, and alleviate symptoms.

Presentation for right heart failure:

  • Peripheral edema (swelling) in the legs, ankles, and abdomen

  • Jugular venous distension (enlarged neck veins)

  • Fatigue and weakness

  • Hepatomegaly (enlarged liver)

  • Ascites (accumulation of fluid in the abdominal cavity)

  • Shortness of breath, especially with exertion

  • Cyanosis (bluish discoloration of the lips or extremities)

  • Rapid or irregular heartbeat

  • Decreased exercise tolerance

  • Swelling in the feet, ankles, or legs

Assessment for right heart failure:

  • Comprehensive medical history to identify potential causes and risk factors

  • Physical examination to assess signs of fluid retention, jugular venous distension, hepatomegaly, and edema

  • Diagnostic tests such as echocardiography, electrocardiogram (ECG), chest X-ray, and pulmonary function tests to evaluate heart function, assess pulmonary hypertension, and identify underlying causes

  • Blood tests to evaluate cardiac biomarkers, assess kidney and liver function, and identify any underlying metabolic abnormalities

  • Assessment of symptoms, exercise capacity, and quality of life through questionnaires or functional assessments

  • Evaluation of comorbid conditions, such as lung diseases or valvular heart disease, which can impact right heart failure management

Differential diagnoses for right heart failure:

  • Left heart failure: The left and right sides of the heart are interconnected, and dysfunction in one side can lead to failure in the other.

  • Pulmonary hypertension: Increased blood pressure in the pulmonary arteries can strain the right side of the heart and result in similar symptoms.

  • Chronic lung diseases: Conditions like chronic obstructive pulmonary disease (COPD) can cause right heart failure-like symptoms due to pulmonary hypertension and compromised lung function.

  • Constrictive pericarditis: Inflammation and stiffening of the pericardium can impair right heart function and mimic right heart failure symptoms.

  • Tricuspid valve disease: Malfunctioning of the tricuspid valve can lead to right heart dysfunction and symptoms resembling right heart failure.

Treatment plan for right heart failure:

  • Addressing the underlying cause: Treating the underlying condition contributing to right heart failure, such as left heart failure or lung diseases.

  • Medications: Prescribing medications such as diuretics, ACE inhibitors, beta-blockers, and vasodilators to reduce fluid retention, improve heart function, and manage pulmonary hypertension.

  • Oxygen therapy: Administering supplemental oxygen to improve oxygenation and relieve symptoms of shortness of breath.

  • Sodium and fluid restriction: Implementing dietary modifications to reduce fluid retention and sodium intake.

  • Cardiac rehabilitation: Referring patients to a cardiac rehabilitation program to optimize exercise tolerance, manage symptoms, and provide education and support.

  • Regular monitoring and follow-up: Monitoring symptoms, medication management, and periodic assessments of cardiac function to ensure effective treatment and manage any changes in the condition.

  • Invasive interventions: In severe cases, individuals with right heart failure may require interventions such as heart transplantation or implantation of a ventricular assist device (VAD) to support heart function.

Prognosis for right heart failure:

The prognosis for right heart failure depends on various factors, including the underlying cause, the severity of symptoms, and the individual’s response to treatment. With appropriate management, lifestyle modifications, and adherence to treatment plans, the prognosis can be improved. However, right heart failure is often a chronic condition that requires ongoing care and monitoring. Close collaboration with healthcare professionals, regular follow-up visits, and adherence to medication and lifestyle recommendations are crucial for optimizing prognosis and maintaining a good quality of life.

Imported to the OHDSI Phenotype Library. It may be expected to be found with id = 766 in the next release. Thank you ‘Joel Swerdel’,‘Eva-maria Didden’;

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