Cohort Definition Name: Primary adenocarcinoma of the colon or rectum, MSI-H or dMMR, no surgery or oncological treatment
Contributor name: Andreas Weinberger Rosen
Contributor OrcId: 0000-0001-9990-8155
Logic Description: First event of primary adenocarcinoma of the colon or rectum with MSI-H or dMMR, no curative surgery or oncological treatment any time after
Recommended study application: exposure. Including a specific molecular subtype of colorectal cancer, where there are no curative treatment options or oncological therapy
Assertion statement: This cohort definition was executed on at least one real person-level observational health data source and resulted in a cohort with at least 1 person.
Submitted cohort definition:
Primary adenocarcinoma of the colon or rectum, MSI-H or dMMR, no surgery or oncological treatment.txt (112.7 KB)
Target Clinical Description
Colorectal cancer, primarily an adenocarcinoma, stands as the most prevalent malignant tumor affecting the intestinal tract. Originating in the epithelial cells that line the colon or rectum, the disease can escalate into a full-fledged malignant tumor through various molecular mechanisms. The disease manifests differently based on its anatomical location, its size, and its stage of development.
Presentation of Colorectal Cancer
Common Symptoms:
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Hematochezia or blood in the stool -
Diarrheal episodes or constipation -
Sensation of incomplete bowel evacuation -
Abdominal discomfort or pain -
Unintentional weight loss -
Nocturnal sweating -
Anemia
Some patients may not display symptoms and are often diagnosed either via screening programs or incidental findings during other medical evaluations.
In some instances, colorectal cancer can escalate into an emergency scenario, leading to complications like bowel obstruction, acute lower gastrointestinal bleeding, or even bowel perforation.
Assessment for Colorectal Cancer
Colonoscopy for macroscopic evaluation and biopsy collection
Histopathology of the biopsy tissue serves as a cornerstone for diagnosis
Various imaging modalities such as CT, PET, and MRI for clinical staging
Histological evaluation of surgical or metastatic samples for pathological staging
Differential Diagnosis of Colorectal Cancer
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Other intestinal neoplasms like neuroendocrine tumors or advanced polyps -
Diverticular disease -
Hemorrhoidal issues -
Anal fissures -
Irritable Bowel Syndrome (IBS) -
Inflammatory Bowel Disease (IBD)
Treatment Plan for Colorectal Cancer
Best supportive care
Prognosis for Colorectal Cancer
The prognosis without curative surgery or supportive oncological therapy is usually poor
Assignment for Peer Review:
Peer review of the phenotype would be more than welcome