Contributor name: LEGEND-T2DM team (individuals in order of authorship in the BMJ Open publication, all authors contributed to these definitions) Rohan Khera Martijn Schuemie @schuemie Yuan Lu @Yuan_Lu Anna Ostropolets @aostropolets RuiJun Chun @rchen George Hripcsak @hripcsa , Patrick Ryan @Patrick_Ryan Harlan Krumholz Marc Suchard @msuchard )
Cohort Definition Names:
In the LEGEND-T2DM study, we conducted population-level effect estimation studies for the comparative effectiveness of diabetes treatments, using cardiovascular outcomes that were related to intended effects as well as labeled adverse events. These outcome list included:
- 3-point MACE
- 4-point MACE
- Acute myocardial infarction
- Acute renal failure
- Glycemic control
- Hospitalization with heart failure
- Measured renal dysfunction
- Revascularization
- Stroke
- Sudden cardiac death
- Abnormal weight gain
- Abnormal weight loss
- Acute pancreatitis
- All-cause mortality
- Bladder cancer
- Bone fracture
- Breast cancer
- Diabetic ketoacidosis
- Diarrhea
- Genitourinary infection
- Hyperkalemia
- Hypoglycemia
- Hypotension
- Joint pain
- Lower extremity amputation
- Nausea
- Peripheral edema
- Photosensitivity
- Renal cancer
- Thyroid tumor
- Venous thromboembolism
- Vomiting
Logic and description:
The full list of outcomes with descriptions are described in the LEGEND-T2DM Git repo as a csv file here: https://github.com/ohdsi-studies/LegendT2dm/blob/master/inst/settings/OutcomesOfInterest.csv
All JSON corresponding to these cohorts are available here: https://github.com/ohdsi-studies/LegendT2dm/tree/master/inst/cohorts/outcome
Note that some of the LEGEND-T2DM definitions were previously used in LEGEND-HTN and are therefore redundant and do not need to be entered into the library again.
Recommended study application: Outcome
Assertion statement: This cohort definition was executed on at least one real person-level observational health data source and resulted in a cohort with at least 1 person.
Citations: These outcome phenotypes have been used in one peer-review publication thusfar, which is the protocol that includes the full outcome cohort definitions as an appendix:
Khera R, Schuemie MJ, Lu Y, Ostropolets A, Chen R, Hripcsak G, Ryan PB, Krumholz HM, Suchard MA. Large-scale evidence generation and evaluation across a network of databases for type 2 diabetes mellitus (LEGEND-T2DM): a protocol for a series of multinational, real-world comparative cardiovascular effectiveness and safety studies. BMJ Open. 2022 Jun 9;12(6):e057977. doi: 10.1136/bmjopen-2021-057977. PMID: 35680274; PMCID: PMC9185490. https://bmjopen.bmj.com/content/12/6/e057977.info