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Phenotype Submission - Inflammatory Bowel Disease

Researchers
#1

Cohort Definition Name: “Inflammatory Bowel Disease”
Contributor name: Joel N. Swerdel
Contributor OrcId: 0000-0001-9491-2737
Logic Description: First occurrence of Inflammatory Bowel Disease.
Recommended study application: outcome, indication
Assertion statement: This cohort definition was executed on at least one real person-level observational health data source and resulted in a cohort with at least 1 person.
Submitted cohort definition:
ibd.txt (10.5 KB)

Target Clinical Description

Inflammatory Bowel Disease (IBD) is a group of chronic, immune-mediated gastrointestinal disorders that cause inflammation and damage to the digestive tract. The two primary forms of IBD are Crohn’s disease and ulcerative colitis. While the exact cause of IBD is not fully understood, it is believed to result from a combination of genetic, environmental, and immunological factors. IBD is characterized by periods of active disease, known as flares, and periods of remission. It can significantly impact a person’s quality of life and requires ongoing management.

Presentation for Inflammatory Bowel Disease:

  1. Abdominal pain and cramping
  2. Diarrhea, often with blood or mucus
  3. Weight loss
  4. Fatigue
  5. Reduced appetite
  6. Urgent and frequent bowel movements
  7. Rectal bleeding (more common in ulcerative colitis)
  8. Mouth sores
  9. Joint pain
  10. Skin problems
  11. Fever

Assessment for Inflammatory Bowel Disease:

  1. Blood tests to assess inflammation (e.g., C-reactive protein, erythrocyte sedimentation rate)
  2. Stool tests to check for infection and inflammation
  3. Imaging studies (e.g., colonoscopy, endoscopy, CT scan) to visualize the digestive tract and assess disease severity
  4. Biopsies of affected tissue for microscopic evaluation
  5. Assessment of disease activity using clinical scoring systems (e.g., Crohn’s Disease Activity Index, Ulcerative Colitis Disease Activity Index)

Differential Diagnoses for Inflammatory Bowel Disease:

  1. Irritable bowel syndrome (IBS)
  2. Celiac disease
  3. Gastroenteritis
  4. Diverticulitis
  5. Colorectal cancer
  6. Infectious colitis (e.g., Clostridium difficile infection)

Treatment Plan for Inflammatory Bowel Disease:

  1. Medications to induce and maintain remission (e.g., aminosalicylates, corticosteroids, immunomodulators, biologics)
  2. Nutritional therapy, including specialized enteral nutrition
  3. Diet modifications (e.g., low-residue diet, specific carbohydrate diet)
  4. Lifestyle management (stress reduction, regular exercise)
  5. Surgical interventions in cases of complications or medication failure (e.g., bowel resection, colostomy)

Prognosis for Inflammatory Bowel Disease: The prognosis for individuals with IBD varies depending on the type and severity of the disease, as well as the effectiveness of treatment. While IBD is a chronic condition with no known cure, many patients can achieve and maintain remission with appropriate management. Long-term complications and the risk of surgery may exist, but advances in treatment options have improved the quality of life for many individuals with IBD.

#2

Of interest this is a recent medical chart validation study of IBD algorithms. Development and Validation of Claims-Based Definitions to Identify Incident and Prevalent Inflammatory Bowel Disease in Administrative Healthcare Databases - PubMed
Additionally these algorithms were utilize to determine “How often” from an incidence and prevalence perspective.
Incidence, Prevalence, and Racial and Ethnic Distribution of Inflammatory Bowel Disease in the United States - PubMed

1 Like
#3

Imported with id 745

#4

Imported to the OHDSI Phenotype Library. It may be expected to be found with id = 775 in the next release. Thank you ‘Joel Swerdel’,‘Eva-maria Didden’;

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