Attach cohort definitions:
Hello @Gowtham_Rao, I am a medical student working with Dr. Toy of USC and Dr. Tavakoli of UCSD, as well as the other members of the uveitis subgroup. We are currently trying to submit Phenotypes for the HowOften initiative.
We respectfully seek your guidance regarding our preliminary cohort definition constructed using the ATLAS platform. While we have plans to submit multiple Phenotypes encompassing various uveitis disease entities, we want to make sure our first one meets the criteria.
We are trying to create a cohort definition for CMV anterior uveitis based on the SUN criteria (PMID: 33845019). We were wondering if you would be able to give us advice on how to best go about creating the cohort definition. We appreciate your consideration of our request. We are looking forward to working with the OHDSI Phenotype Development and Evaluation workgroup as we develop Phenotypes for various uveitis disease entities. We hope to contribute to the OHDSI Phenotype library. Thank you.
[we will be filling in continuously]
Cohort Definition Names: CMV Anterior Uveitis
Contributor names: tbd
Clinical description: Computable definition of SUN classification criteria for CMV anterior uveitis
Logic description:
Shiley Eye Institute, University of California San Diego
Rupesh Agrawal
National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore
Karen Armbrust
0000-0001-9381-4756
Minneapolis VA Health Care System, University of Minnesota
Kareem Moussa
UC Davis
Jessica Shantha
UCSF
Edmund Tsui
0000-0001-7532-9191
UCLA Stein Eye Institute, David Geffen School of Medicine at UCLA
Brian Toy
0000-0002-9612-5697
Roski Eye Institute, Keck School of Medicine, USC
Clinical description: Computable definition of SUN classification criteria for CMV anterior uveitis. This phenotype is of patients with a diagnosis or clinical findings of anterior uveitis that is consistent with an etiology of cytomegalovirus (CMV) infection. This phenotype operationalizes the definition published by the SUN workgroup (Classification Criteria for Cytomegalovirus Anterior Uveitis - PubMed (nih.gov))
Logic description:
Inclusion
Evidence of anterior uveitis
a. anterior chamber cells
b. if anterior vitreous cells are present, anterior chamber inflammation should be present
c. no evidence of retinitis
AND
Evidence of cytomegalovirus infection in the eye
a. Positive PCR* for cytomegalovirus on aqueous specimen
Exclusions
Positive serology for syphilis using a treponemal test
Evidence of sarcoidosis (either bilateral hilar adenopathy on chest imaging or tissue biopsy demonstrating non-caseating granulomata)
Aqueous specimen PCR positive for herpes simplex virus or varicella zoster virus
Hello @Gowtham_Rao thank you for all your help in constructing our phenotype. We were wondering if we can add some amendments to our post above? Should I just post them in the forum thread here? However, I believe I’m not allowed to post links to the cohort definitions.
