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Phenotype Submission - Chronic Graft Versus Host Disease (GVHD)

Cohort Definition Name : Earliest event of Chronic Graft Versus Host Disease (GVHD)

Contributor name : Jill Hardin

Contributor OrcId :

Logic Description : Earliest occurrence of Chronic graft-versus-host disease indexed on diagnosis date of Chronic graft-versus-host disease or acute on Chronic graft-versus-host disease (for the first time in history) or unspecified raft-versus-host disease with a Hematopoietic Stem Cell Transplantation (HSCT) anytime prior to 180 days prior to index, cohort exit is the end of continuous observation

Recommended study application : target

Assertion statement : This cohort definition was executed on at least one real person-level observational health data source and resulted in a cohort with at least 1 person.

Target Clinical Description : Graft-versus-host disease (GVHD) is a potentially serious complication of allogeneic stem cell or bone marrow transplantation, in which a patient receives stem cells or bone marrow from a donor. GVHD occurs when the donor’s T cells (the graft) identify the patient’s healthy cells (the host) as foreign and attack them. There are acute (starting within 100 days after transplant) and chronic (appearing any time or years after transplant) GVHD. Chronic GVHD is the indication we want to phenotype, we are NOT interested in acute or general GVHD.

Evaluation conclusion : We developed incident and prevalent cohort definitions for chronic graft versus host disease (cGVHD) which incorporated codes found from the literature review and from the analysis of PHOEBE and orphan concepts in cohort diagnostics. We performed the evaluation across a network of claim data sources and 1 EHR US data source. The data sources are: IBM® MarketScan® Commercial Database (CCAE), Optum’s longitudinal EHR repository (Optum EHR), Optum’s Clinformatics® Data Mart (DOD), IBM® MarketScan® Multi-State Medicaid Database (MDCD), IBM® MarketScan® Medicare Supplemental Database (MDCR), Japan Claims Database (JMDC), Clinical Practice Research Datalink (CPRD) , IQVIA® Australia Longitudinal Patient Data (LPD) database (Australia), IQVIA® Disease Analyzer (DA) France database (France), QVIA® Disease Analyzer (DA) Germany database (Germany), IQVIA® Adjudicated Health Plan Claims Data (formerly PharMetrics Plus) - US database (PharMetrics), IQVIA® Ambulatory EMR (EMR) . The incident algorithm retrieves subjects from all 6 databases tested. Phevaluator estimates for sensitivity ranged from 0.33 to 0.60 and PPV ranged from 0.53 to 0.75

Imported to the OHDSI Phenotype Library. It may be expected to be found with id = 1010 in the next release. Thank you