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Phenotype Submission - Birdshot Chorioretinitis

Contributor ORCID Organization
Edward Lee N/A Roski Eye Institute, Keck School of Medicine, USC
Kiana Tavakoli 0000-0003-1883-9018 Shiley Eye Institute, University of California San Diego
Rupesh Agrawal 0000-0002-6662-5850 National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore
William Rojas Carabali 0000-0002-9976-8989 Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore
Karen Armbrust 0000-0001-9381-4756 Minneapolis VA Health Care System, University of Minnesota
Kareem Moussa 0000-0001-9110-9594 Department of Ophthalmology & Vision Science, University of California, Davis
Jessica Shantha 0000-0002-4449-8598 F.I. Proctor Foundation, University of California, San Francisco
Edmund Tsui 0000-0001-7532-9191 UCLA Stein Eye Institute, David Geffen School of Medicine at UCLA
Brian Toy 0000-0002-9612-5697 Roski Eye Institute, Keck School of Medicine, USC
  • Clinical description: Computable definition of SUN classification criteria for Birdshot chorioretinitis. This phenotype is of patients with a diagnosis or clinical findings of posterior uveitis consistent with birdshot chorioretinitis. This phenotype operationalizes the definition published by the SUN workgroup (PMID 33845003)

Criteria ([#’s 1, 2, and 3] OR # 4)

  1. Characteristic bilateral multifocal choroiditis on ophthalmoscopy
    a. Multifocal cream-colored or yellow-orange, oval or round choroidal lesions (“birdshot spots”)
  2. Absent to mild anterior chamber inflammation
    a. Absent to mild anterior chamber cells AND
    b. No keratic precipitates AND
    c. No posterior synechiae
  3. Absent to moderate vitritis
  4. Multifocal choroiditis with
    a. Positive HLA-A29 test AND either (b. or c.)
    b. Characteristic “birdshot” spots (multifocal cream-colored or yellow-orange, oval or round choroidal lesions) on ophthalmoscopy OR
    c. Characteristic indocyanine green angiogram (multifocal hypofluorescent spots) without characteristic “birdshot” spots on ophthalmoscopy
  5. Positive serologic test for syphilis using a treponemal test
  6. Evidence of sarcoidosis (either bilateral hilar adenopathy on chest imaging or tissue biopsy demonstrating non-caseating granulomata)*
  7. Evidence of intraocular lymphoma on diagnostic vitrectomy or tissue biopsy