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Phenotype Submission - Birdshot Chorioretinitis [Birdshot International Consensus Conference]

Researchers
#1
Contributor ORCID Organization
Edward Lee N/A Roski Eye Institute, Keck School of Medicine, USC
Kiana Tavakoli 0000-0003-1883-9018 Shiley Eye Institute, University of California San Diego
Rupesh Agrawal 0000-0002-6662-5850 National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore
William Rojas Carabali 0000-0002-9976-8989 Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore
Karen Armbrust 0000-0001-9381-4756 Minneapolis VA Health Care System, University of Minnesota
Kareem Moussa 0000-0001-9110-9594 Department of Ophthalmology & Vision Science, University of California, Davis
Jessica Shantha 0000-0002-4449-8598 F.I. Proctor Foundation, University of California, San Francisco
Edmund Tsui 0000-0001-7532-9191 UCLA Stein Eye Institute, David Geffen School of Medicine at UCLA
Brian Toy 0000-0002-9612-5697 Roski Eye Institute, Keck School of Medicine, USC
  • Clinical description: Computable definition of BICC classification criteria for birdshot chorioretinitis. This phenotype is of patients with a diagnosis or clinical findings of posterior uveitis consistent with birdshot chorioretinitis. This phenotype operationalizes the definition published by the investigators who attended the international conference on birdshot chorioretinitis (PMID 16386995)

Inclusion
Criteria ([#’s 1-4)

  1. Bilateral disease
  2. Presence of at least 3 peripapillary “birdshot lesions” inferior or nasal to the optic disc in one eye
    a. Cream-colored, irregular or elongated, choroidal lesions with indistinct borders, the long axis of
    which is radial to the optic disc (“birdshot spot”)
  3. <=1+ cells in the anterior chamber
  4. <=2+ vitreous haze

Supportive findings

  1. HLA-A29 positivity
  2. Retinal vasculitis
  3. Cystoid macular edema

Exclusion

  1. Keratic precipitates
  2. Posterior synechiae
  3. Presence of infectious, neoplastic, or other inflammatory diseases that can cause multifocal choroidal lesions

*Logic description:

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Recommended Study applications: target

Submitted cohort definition:: [ATLAS: Cohort Definitions (ohdsi.org)]

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