Phenotype Phebruary Day 14 - Hypertension (emphasis on clinical description)

1. B) I then write up my short version of the reading - call it G-notes

Hypertension:

Overview: 
	Chronic elevation of blood pressure - defined in 2017 Hypertension guidelines (normal, elevated, stage 1 hypertension, stage 2 hypertension)
	
Presentation:
	Most people asymptomatic - so true biological index date is not possible? Headache, dizziness or blurred vision.
	
	
Assessment:
	Etiology unknown in 90% - essential hypertension, but rule out secondary correctable form of hypertension especially if <= 30 or >= 55 years.
	Terms associated with Hypertension:
		- Normal, Elevated, Stage 1, Stage 2
		- Isolated Systolic hypertension
		- Controlled vs uncontrolled hypertension
		- Incident vs Prevalent hypertension
		- Malignant Hypertension - medical emergency
		- SPRINT hypertension definition - resting blood pressure.
	Secondary causes:
		- Renal artery stenosis (renovascular hypertension)
		- Renal Parenchymal Disease (Chronic Kidney Disease)
		- Coaractation of Aorta - children or young adults
		- Pheochromocytoma- sudden episodes, elevated plasma metanephrine
		- Hyperaldosteronism
		- Drugs - drugs (oral contraceptives, erythropoetin, decongestants, NSAIDs, glucorticoids, cyclosporine) obstructive sleep apnea, cushings disease, thyroid disease, hypercalcemia, acromegaly
		
Differential Diagnosis:
	Secondary causes - Hyperaldosteronism, coarctation of the aorta, renal artery stenosis, chronic kidney disease, and aortic valve disease 
Plan:
	Screen:
		- Kidney related: Serum creatinine, BUN, urinalysis, 
		- Cardiovascular evaluation: CXR, ECG
		- Thyroid: TSH
		
	Manage:
		- Control blood pressure with minimal side effect
		- First line treatment: Diuretics, ACE inhibitors, ARB, CCB, beta blockers
		
Prognosis:
	Except for secondary hypertension, is chronic. If untreated, will most likely progress
		Cardiovascular diseases and complications - acute myocardial infarction, congestive heart failure, stroke etc.
	
Other:
	Definition:
		Normal blood pressure – Systolic <120 mmHg and diastolic <80 mmHg
		Elevated blood pressure – Systolic 120 to 129 mmHg and diastolic <80 mmHg
		Hypertension:
			Stage 1 – Systolic 130 to 139 mmHg or diastolic 80 to 89 mmHg
			Stage 2 – Systolic at least 140 mmHg or diastolic at least 90 mmHg
			If there is a disparity in category between the systolic and diastolic pressures, the higher value determines the stage.

	Anecdotes:
		High prevalence
		Hypertension treatment is most common reason for office visit + source of hypertensive medication dispensation
		Adequate blood pressure is low