OHDSI MEETINGS THIS WEEK
Patient Visualization Work Group Meeting - Tuesday at 2pm ET
ANNOUNCEMENTS
OHDSI Data Network Table - Help us update it! http://www.ohdsi.org/web/wiki/doku.php?id=resources:data_network beaton@ohdsi.org .
OHDSI Symposium 2016 - REGISTER NOW! http://www.ohdsi.org/events/ohdsi-symposium-2016/1
OHDSI Symposium 2016 - Call for participation http://www.ohdsi.org/ohdsi-symposium-2016-call-for-participation/
COMMUNITY PUBLICATIONS
FALDO: a semantic standard for describing the location of nucleotide and protein feature annotation.
JT Bolleman, CJ Mungall, F Strozzi, J Baran, M Dumontier, RJ Bonnal, R Buels, R Hoehndorf, T Fujisawa, T Katayama and PJ Cock,
Journal of biomedical semantics , Jun 2016 13
Nucleotide and protein sequence feature annotations are essential to understand biology on the genomic, transcriptomic, and proteomic level. Using Semantic Web technologies to query biological annotations, there was no standard that described this potentially complex location information as subject-predicate-object triples.We have developed an ontology, the Feature Annotation Location Description Ontology (FALDO), to describe the positions of annotated features on linear and circular sequences. FALDO can be used to describe nucleotide features in sequence records, protein annotations, and glycan binding sites, among other features in coordinate systems of the aforementioned "omics" areas. Using the same data format to represent sequence positions that are independent of file formats allows us to integrate sequence data from multiple sources and data types. The genome browser JBrowse is used to demonstrate accessing multiple SPARQL endpoints to display genomic feature annotations, as well as protein annotations from UniProt mapped to genomic locations.Our ontology allows users to uniformly describe - and potentially merge - sequence annotations from multiple sources. Data sources using FALDO can prospectively be retrieved using federalised SPARQL queries against public SPARQL endpoints and/or local private triple stores.
Radiation Therapy-First Strategy After Surgery With or Without Adjuvant Chemotherapy in Stage IIIA-N2 Non-Small Cell Lung Cancer.
HW Lee, OK Noh, YT Oh, JH Choi, M Chun, HI Kim, J Heo, MS Ahn, SY Park, RW Park and D Yoon,
International journal of radiation oncology, biology, physics , Mar 2016 01
Postoperative radiation therapy (PORT) and postoperative chemotherapy (POCT) can be administered as adjuvant therapies in patients with non-small cell lung cancer (NSCLC). The aim of this study was to present the clinical outcomes in patients treated with PORT-first with or without subsequent POCT in stage IIIA-N2 NSCLC.From January 2002 to November 2014, the conditions of 105 patients with stage IIIA-N2 NSCLC who received PORT-first with or without subsequent POCT were analyzed. PORT was initiated within 4 to 6 weeks after surgical resection. Platinum-based POCT was administered 3 to 4 weeks after the completion of PORT. We analyzed the outcomes and the clinical factors affecting survival.Of 105 patients, 43 (41.0%) received POCT with a median of 4 cycles (range, 2-6 cycles). The follow-up times ranged from 3 to 123 months (median, 30 months), and the 5-year overall survival (OS) was 40.2%. The 5-year OS of patients treated with PORT and POCT was significantly higher than that of patients with PORT (61.3% vs 29.2%, P<.001). The significant prognostic factors affecting OS were the use of POCT (hazard ratio [HR] = 0.453, P=.036) and type of surgery (pneumonectomy/lobectomy; HR = 2.845, P<.001).PORT-first strategy after surgery appeared not to compromise the clinical outcomes in the treatment of stage IIIA-N2 NSCLC. The benefit of POCT on OS was preserved even in the PORT-first setting. Further studies are warranted to compare the sequencing of PORT and POCT, guaranteeing the proper use of POCT.
Co-creating value through demand and supply integration in senior industry-observations on 33 senior enterprises in Taiwan.
YT Yang, U Iqbal, YM Chen, S Su, YM Chang, Y Handa, NP Lin and YH Hsu,
International journal for quality in health care : journal of the International Society for Quality in Health Care , Sep 2016
With global population aging, great business opportunities are driven by the various needs that the elderly face in everyday living. Internet development makes information spread faster, also allows elderly and their caregivers to more easily access information and actively participate in value co-creation in the services. This study aims to investigate the designs of value co-creation by the supply and demand sides of the senior industry.This study investigated senior industry in Taiwan and analyzed bussiness models of 33 selected successful senior enterprises in 2013. We adopted series field observation, reviews of documentations, analysis of meeting records and in-depth interviews with 65 CEOs and managers.Thirty-three quality enterprises in senior industry.Sixty-five CEOs and managers in 33 senior enterprises.None.Value co-creation design, value co-creating process.We constructed a conceptual model that comprehensively describes essential aspects of value co-creation and categorized the value co-creation designs into four types applying for different business models: (i) interaction in experience spaces co-creation design, (ii) on-site interacting co-creation design, (iii) social networking platform co-creation design and (iv) empowering customers co-creation design. Through value co-creation platform design, the senior enterprises have converted the originally passive roles of the elderly and caregivers into active participants in the value co-creation process.The new paradigm of value co-creation designs not only promote innovative development during the interactive process, lead enterprises reveal and meet customers' needs but also increase markets and profits.
