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Missing NDC/HCPCS Codes and Missing Maps to RxNorm

#1

I am working with the ‘CanMED: Cancer Medications Enquiry Database’ from the NCI/SEER Observational Research in Oncology Toolbox (see here https://seer.cancer.gov/oncologytoolbox/) in hopes that it can be used for the vocabulary portion of the Oncology Treatment Proposal (see here: https://github.com/OHDSI/CommonDataModel/issues/163). CANMed classifies low-level NDC/HCPCS codes to higher-level concepts: ‘Minor Class’, ‘Major Class’ and a ‘SEERRx Category’. Importantly, CanMED’s highest level classification, the 'SEERRx Category’, can be mapped to NAACCR/SEER data items. This could be the basis for the ability to crosswalk between EHR oncology treatment data and tumor registry oncology treatment data.

As part of my analysis of CanMED I want to map its NDC/HCPCS codes to RxNorm codes. I am using the OMOP vocabulary to achieve the mappings to RxNorm. I have found some missing codes and mappings within the OMOP vocabulary.

Missing NDC codes: 25
https://drive.google.com/open?id=1ZOAz34rkGv_efF0Bm7o8CILzwvpDhnVg

NDC codes with no map to RxNorm: 118
https://drive.google.com/open?id=1sFUM_T77-bJWLBzO8IdMjvB2-u19NRiM

Missing HCPCS codes: 41
https://drive.google.com/open?id=16v3SeCNUff-yWicLT-na97I9bE5_1rHd

HCPCS codes with no map to RxNorm: 54
https://drive.google.com/open?id=1X8o8M6SJU8bKg5V12PkclqKjbKoNt0tC

Could these missing items be addressed?

Missing NDC and HCPCS in OMOP and Athena
#2

Hi @mgurley,

this mappings are ready to the release, so we’ll add them shortly.

#3

And regarding missing concepts: please send us codes, their names, valid start and valid end dates, so we can incorporate them. While with HCPCS it’s relatively easy, NDC will require additional checks with the existing set of missing concepts. Sometimes we just see some random codes there like 9999999999

#4

Here is the full information provided by NCI/SEER in their CanMED database for the NDC/HCPCS codes missing in OMOP.

omop_missing_hcpcs_codes_full.csv
https://drive.google.com/open?id=1_j26m8YiOaz6qexXZwC5avU9-Cie-lKC

omop_missing_ndc_codes_full.csv
https://drive.google.com/open?id=1_UWaqOicKxoZJacKMJLgC2-Le4jTMrd8

If this is insufficient, let me know, I can ask NCI/SEER for the source files they pulled the codes from to fill in any missing information.

#5

@mgurley

mappings are already on Athena,
except for
these two missed somehow, so we’ll add the mapping in the next run:
S0116 BEVACIZUMAB
J9020 Injection, asparaginase, not otherwise specified, 10,000 units

these can’t be mapped as they are very general
J3590 Unclassified biologics
J8499 Prescription drug, oral, non chemotherapeutic, nos
J8999 Prescription drug, oral, chemotherapeutic, nos
J9999 Not otherwise classified, antineoplastic drugs
S2107 Adoptive immunotherapy i.e. development of specific anti-tumor reactivity (e.g., tumor-infiltrating lymphocyte therapy) per course of treatment
S9338 Home infusion therapy, immunotherapy, administrative services, professional pharmacy services, care coordination, and all necessary supplies and equipment (drugs and nursing visits coded separately), per diem

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HCPCS codes change their meaning over time
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