Mapping Microbiology Susceptibility into OMOP CDM4 Observations

Friends:

Sounds like somebody, or any of you, might want to step up. This keeps coming back every now and then.

A couple points:

  • Put the organisms into the Measurement, not the Meas Value. So, “Streptococcus in blood culture” - “detected”/“not detected”, rather than “Blood culture” - “streptococcus” (which I believe is what you have in mind, @HeideNei). Reason: The analyst should find what’s important in one place and not having to search around.
  • Same is true for the antibiotic sensitivity: “Sensitivity to Vancomycin” - “Sensitive”/“Not sensitive”
  • There is a question if you even need a negative result, and whether positive blood cultures and sensitivities is sufficient for the use cases. I would always err on the side of simplicity.
  • Leaves us with the question of how to combine them, i.e. that the strep is sensitive to vancomycin. One way is to use FACT_RELATIONSHIP to connect the otherwise two independent records. Alternatively, you create all meaningful combinations, like “Streptococcus sensitive to vancomycin”. Shouldn’t be that many. I think @cukarthik might have such a list as a starting point.

Once that is ready, we can add it to the Vocabularies and maybe put some Themis rules in place how to do that.