An important potential use of observational data in oncology for both regulatory and HTA decision making is in forming external control groups. With IPD from a trial (usually single arm) and external controls matching methods can be used to estimate comparative effectiveness.
In many ways, the OHDSI/EHDEN data networks offer a great opportunity to support this by helping with data identification and access.
However, a federated data network also acts against this because data sets (trial and observational) cannot be combined (unless both are in possession of those undertaking analysis).
I would be interested in hearing people’s perspective on the value of the OHDSI/EHDEN networks for estimating comparative effectiveness using external controls. Is this something anyone has given any thought to?