@BridgetWang and I are revisiting the Population Level Estimation study on Xeljanz that we started at the F2F at Columbia last May – which is an attempt at recreating parts of this study. We are focusing on Major Adverse Cardiovascular Events (MACE). Since it’s a composite, we’ve broken it into 3 separate Os: acute myocardial infarction, stroke and cardiovascular-related death. We have 2 of these from LEGEND but we’re struggling with cardiovascular related death and could use some support from the community.
So we’re asking the community: does anyone have an existing O cohort definition for cardiovascular related death? We think this endpoint is valuable in recreating a MACE definition but we’re not entirely sure if this is well captured in real world data. Any advice on how others have approached this would be super helpful. We’d like to pull from the knowledge of the crowd here (cough cough: @jon_duke @hripcsa @rchen @Patrick_Ryan @Gowtham_Rao etc etc )