I am seeking to identify all potential indications for systemic corticosteroids and was thinking of trying to build a concept set that includes these. I haven’t seen anything similar, but does anyone know if this already exists? I’d appreciate any input.
You picked the worst drug class. Half of ICD10 can be treated with it, either directly, or sequelae or other consequences. Some conditions are both indication and contraindication (e.g. Covid-19).
What are you trying to do?
@Christian_Reich yes it is. We are trying to capture systemic steroids (i.e., not topical formulations) used for the treatment of atopic dermatitis.
Why not use the Dose Form in RxNorm.
Hi, @tsivesind
If you had ATLAS linked with any CDM database, you could see record counts and descendant record counts. If your study will be doing in your site-specific, you can check the concepts manually and fit your intended.
However, if you want to perform multi-site analysis, as @Christian_Reich mentioned, you have to include all concepts in the world, you would better use the concept hierarchy. All corticosteroids except topical or focal formulation of corticosteroids.
To my knowledge, RxNorm has no classification top concept like “corticosteroids” including all ingredients but the ATC hierarchy has it. so If you don’t have all the ingredient concepts of steroids, maybe you can use the ATC hierarchy also for picking all ingredients.
Thanks for the advice @Chungsoo_Kim and @Christian_Reich. This is intended to be a multi-site study, so I believe using the ATC hierarchy to pick all ingredients makes the most sense. I appreciate your help!
Be careful with ATC. They tend not to always include all attributes. For example, there is 21605164 (S02B) “CORTICOSTERIODS”. But if you look into the hierarchy they are all otologicals. For systemic, you want to try 21602728 (H02AB) “Glucocorticoids” and * 21602746 (H02BX) “Corticosteroids for systemic use, combinations” and their children.
Or better, you pick all Clinical Drug Forms that combine glucocorticosteriods with systemic Dose forms:
| concept_id | Ingredient name |
|---|---|
| 1115572 | beclomethasone |
| 920458 | betamethasone |
| 939259 | budesonide |
| 902938 | ciclesonide |
| 19050907 | cloprednol |
| 1507705 | cortisone |
| 19061907 | cortivazol |
| 19086888 | deflazacort |
| 1518254 | dexamethasone |
| 1196514 | flunisolide |
| 996541 | fluocinolone |
| 955252 | fluocinonide |
| 19055344 | fluocortolone |
| 955583 | fluorometholone |
| 1149380 | fluticasone |
| 975125 | hydrocortisone |
| 19009116 | meprednisone |
| 1506270 | methylprednisolone |
| 905233 | mometasone |
| 19027186 | paramethasone |
| 1550557 | prednisolone |
| 1551099 | prednisone |
| 19011127 | prednylidene |
| 977421 | rimexolone |
| 19078460 | tixocortol |
| 903963 | triamcinolone |
| concept_id | Dose Form name |
|---|---|
| 46234466 | Auto-Injector |
| 19082103 | Injectable Solution |
| 19082104 | Injectable Suspension |
| 46234469 | Injection |
| 46275062 | Jet Injector |
| 46234467 | Pen Injector |
| 19126920 | Prefilled Syringe |
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