We need a consult for a Atlas cohort definition.
Imagine a scenario where one pain killer is not enough for Osteoarthritis (OA) pain and a researcher needs to go after severe osteoarthritis (to compare patients with knee replacement; T) with truly severe cases of OA(as C). IC stands for Inclusion Criterion.
Option 1a (eras)
Initial event : NSAID painkiller (set1 of ingredients) is defined and using DRUG_ERA
IC1: second stronger painkiller (set2 of ingredients; not overlapping with set1)
IC2: for Dx prior index (or at index)
Option 1b (eras but different order (winner so far)
(variant of 1a but: strong painkiller is initial event and mild painkiller is in IC1
(we would prefer to have index date the date of the intensive therapy
Option 2 (dx as index)
Index event is onset of Osteoarthritis (Dx onset index time).
IC1 and IC2 for painkillers
Option 3 (drug exposure)
well, eras would be best but did others have similar problem ever?
Has any one encountered 2 concurrent drug criterion before and what was your approach? (or any advice you have for us would be appreciated)
In fact, alternatively, we would enumerate one large superset of ingredients and we would look for 2 concurrent ingredients from the superset. (I would think currently either not supported by Atlas or requires power user help) @Chris_Knoll ?