The Women of OHDSI working group wants to run a study and are looking for clinical research questions! We’re calling on the OHDSI community to propose research questions which we will then use to prepare our study design.
If you would like to propose a question, please respond to this thread by Monday, May 20th with your research question. To help you formulate your question, we’ve provided simple ‘fill in the blanks’-style templates below:
Template for Estimation Questions:
To compare the risk of [insert outcome of interest here] between [insert target exposure here] and [insert comparator cohort here] we will estimate the population-level effect of exposure on the [Insert the metric of your analysis model here: hazards for Cox/ odds for logistic / rate ratio for Poisson] of the outcome during the period from [Insert time-at-risk start: e.g. 1 day after exposure start] to [Insert time-at-risk end: e.g. 30 days after exposure end] .
To compare the risk of angioedema between new users of levetiracetam and new users of phenytoin , we will estimate the population-level effect of exposure on the hazards of the outcome during the period from 1 day after exposure start to 0 days after exposure end
Estimation questions can focus on safety surveillance, comparing treatment options, and investigate treatment pathways more indepth. For more support formulating an estimation question, please check out Patrick’s forum post outlining possible research questions for the 2018 OHDSI F2F: OHDSI Face-to-Face at Columbia May2-3: Community study-a-thon
Template for Prediction Questions:
Among patients who [insert patient cohort], which patients will go on to have [insert outcome of interest] within [time window].
Of patients newly diagnosed with major depressive disorder, which patients will go on to have a suicidal event within 1-year of their diagnosis.
Prediction questions can focus on disease onset and progression, treatment choice, treatment response, treatment safety and treatment adherence.