Currently we are working on MedDRA clean up and one of the tasks here is proper domain assignment.
So, there are such a concepts like
|42889410||Acquired gene mutation|
|42889957||Paravaccinia virus test positive|
|42892934||BK polyomavirus test positive|
that stand for the test results
We have similar type of concepts in SNOMED that describes the test and its result:
4135410 BRCA1 gene mutation positive
4135411 BRCA2 gene mutation positive
Currently these concepts have “Condition” domain. the logic behind: some patient condition is stated.
and also a lot of test results interfer with syndromes and disorders, like “Red blood cell count decreased” = “Anemia”, “Granulocytes level increased” = “Granulocytosis”, etc etc.
So not to confuse these we decided that all should be conditions.
please look here:
But on the other Hand it make sense to put a concepts in a Measurement domain, so,
If I want to find all patients with “BRCA1 gene mutation positive”
I will search for
measurement_concept_id = “BRCA1 gene mutation test” with value_as_concept_id ='Positive"
measurement_concept_id = “BRCA1 gene mutation positive”, because both variants can be present in a data.
Thus I need to look onto MEASUREMENT only.
Currently I need to look on
“BRCA1 gene mutation test” with value ='Positive"
“BRCA1 gene mutation positive” in CONDITION domain.