OHDSI MEETINGS THIS WEEK
CDM work group meeting - Tuesday at 1pm EThttps://imshealth.webex.com/mw3000/mywebex/default.do?service=1&siteurl=imshealth&nomenu=true&main_url=%2Fmc3000%2Fe.do%3Fsiteurl%3Dimshealth%26AT%3DMI%26EventID%3D534347467%26UID%3D0%26Host%3DQUhTSwAAAAJGoQPBhYIiWL9gqYIQ2zOyDR1OBuFoZarWuiIBLmsMv-ExtzArDYX5vIh0aHpp6IbrXiuzrzFsvQlqBeYQKPbq0%26FrameSet%3D2%26MTID%3Dm8728276b244be469f2b94609b2e68657
Pharmacovigilance evidence investigation (LAERTES) Workgroup - Tuesday at 3pm EThttps://global.gotomeeting.com/join/530277469
Patient-Level prediction work group meeting (West) - Wednesday at 12pm EThttps://global.gotomeeting.com/join/972917661
NLP work group meeting - Wednesday at 3pm EThttps://global.gotomeeting.com/join/707196421
Architecture WG meeting - Thursday at 1pm EThttps://jjconferencing.webex.com/mw3000/mywebex/default.do?service=1&main_url=%2Fmc3000%2Fe.do%3Fsiteurl%3Djjconferencing%26AT%3DMI%26EventID%3D283835502%26MTID%3Dmb7e839a762fbdaab0608f27500679223%26Host%3DQUhTSwAAAAJeWdHi8LngOQ9smApIpbVefhBBenkejOWGXHugpWO1FS9D3MOVZippskL4ZSabmOUGCl_S82DbDobKaieECNwY0%26FrameSet%3D2&siteurl=jjconferencing&nomenu=true
ANNOUNCEMENTS
OHDSI F2F - Registration is now open for the OHDSI F2F to take place on March 17-18th at GeorgiaTech in Atlanta. Register here:http://www.ohdsi.org/events/2017-ohdsi-collaborator-face-to-face/
People will forget what you said, people will forget what you did, but people will never forget how you made them feel
COMMUNITY PUBLICATIONS
New insights into highly potent tyrosinase inhibitors based on 3-heteroarylcoumarins: Anti-melanogenesis and antioxidant activities, and computational molecular modeling studies
Multisite Evaluation of a Data Quality Tool for Patient-Level Clinical Data Sets.
V Huser, FJ DeFalco, M Schuemie, PB Ryan, N Shang, M Velez, RW Park, RD Boyce, J Duke, R Khare, L Utidjian and C Bailey,
EGEMS (Washington, DC) , 2016
Data quality and fitness for analysis are crucial if outputs of analyses of electronic health record data or administrative claims data should be trusted by the public and the research community.We describe a data quality analysis tool (called Achilles Heel) developed by the Observational Health Data Sciences and Informatics Collaborative (OHDSI) and compare outputs from this tool as it was applied to 24 large healthcare datasets across seven different organizations.We highlight 12 data quality rules that identified issues in at least 10 of the 24 datasets and provide a full set of 71 rules identified in at least one dataset. Achilles Heel is a freely available software that provides a useful starter set of data quality rules with the ability to add additional rules. We also present results of a structured email-based interview of all participating sites that collected qualitative comments about the value of Achilles Heel for data quality evaluation.Our analysis represents the first comparison of outputs from a data quality tool that implements a fixed (but extensible) set of data quality rules. Thanks to a common data model, we were able to compare quickly multiple datasets originating from several countries in America, Europe and Asia.
Furvina inhibits the 3-oxo-C12-HSL-based quorum sensing system of Pseudomonas aeruginosa and QS-dependent phenotypes.
A Borges, P Sousa, A Gaspar, S Vilar, F Borges and M Simões,
Biofouling , 2017 02
Disruption of cell-cell communication or quorum sensing (QS) is considered a stimulating approach for reducing bacterial pathogenicity and resistance. Although several QS inhibitors (QSIs) have been discovered so far their clinical use remains distant. This problem can be circumvented by searching for QSI among drugs already approved for the treatment of different diseases. In this context, antibiotics have earned special attention. Whereas at high concentrations antibiotics exert a killing effect, at lower concentrations they may act as signaling molecules and as such can modulate gene expression. In this study, the antibiotic furvina was shown to be able to cause inhibition of the 3-oxo-C12-HSL-dependent QS system of Pseudomonas aeruginosa. Furvina interacts with the LasI/LasR system. The data were validated by modeling studies. Furvina can also reduce biofilm formation and decrease the production of QS-controlled virulence factors.
