Full details posted here : OHDSI Phenotype Phebruary and workgroup updates - #71 by Gowtham_Rao
Youtube https://youtu.be/vmRWfCBb6OQ
Executive summary:
During the February 5th Phenotype Phebruary 2025 Office Hours, participants focused on five main areas of collaboration and methodological refinement. First, they confirmed that all current study materials must be stored in the Teams Phenotype Workgroup folder for easy access, eventually transferring finalized cohorts and code to GitHub for broader community use. Next, the group discussed methods for searching and reusing existing phenotype definitions, including the OHDSI Phenotype Library, Shiny-based cohort diagnostics, VA’s Cipher platform, and external resources such as Darwin and Sentinel. They stressed verifying definitions for suitability and converting them into Atlas-compatible formats when necessary.
Participants then reviewed best practices for phenotype development and validation, emphasizing both qualitative (clinical expertise) and quantitative (cohort diagnostics) measures, along with tools like PheValuator and Keeper. This stepwise, iterative approach aims to ensure robust, multi-site applicability. A detailed discussion on pediatric vision screening illustrated the complexities of defining non-disease phenotypes: it requires procedure-based logic, complementary comparator cohorts (e.g., well-child visits), and careful attention to data capture inconsistencies. Finally, the conversation turned to Kevin’s progress on Ulcerative Colitis and Crohn’s Disease phenotypes, which will incorporate “enhanced” treatment pathway analyses (e.g., switching behaviors, durations). These will soon transition from the J&J Library to OHDSI’s Library, aligning with network standards and improving cross-site comparability.