None. Was done manually. I know what you want: You want to automate this selection. This was discussed a few times before, like here.
The problem is it doesn’t work very well. Because these indications are not at the same level that usual
diagnostic codes have. I give you an example. There is an antibiotic amikacin. One of the indications is “Pediatric fever without a source”. There is no such a SNOMED concept, because the Condition is “fever”, and the fact that is pediatric is part of the demographic information (year of birth less than 18 years away from current year). So, it gets mapped to “fever”. There are tons of drugs to treat fever, including aspirin, diphenhydramine, caffeine. Hardly comparators for an i.v. antibiotic.
So, nice idea, but won’t work.
Exactly. Ingredients can have very different indications depending in which combination they are.
Another good idea, but this stuff is not clean enough for any such heuristics to work.
I’d say go for the Legend project.