Hi Roshanthi!
There was an attempt to model rich genome data using the extension to the CDM, but it didn’t gain widespread adoption.
Lately, the Onco WG has done another attempt through the closed world content modeling approach. You can learn about it here and here. This is a standard now, but we’re looking for resources to maintain and expand it.
And yes, that OMOP Extension concept is the standard since SNOMED and other vocabularies didn’t have one.
BTW, what problem do you want to solve?