Hi. My name is John Welsh. I work at the Vaccine Research Institute of San Diego as CEO and chief bottle washer. My research has focused lately on how gene expression changes when cancer cells first encounter tissue to which they metastasize. In one study, we identified genes that become up-regulated when breast cancer cells are cultured in vivo on brain tissue in a mouse model (https://doi.org/10.1371/journal.pone.0101160). Interestingly, several of the genes that are temporarily up-regulated as breast cancer cells adapt to brain tissue can be suppressed with commonly used drugs, including ibuprofen, dramamine, and MAOA inhibitors, which are antidepressants. I am wondering whether observational data on patients with breast cancer who routinely use one of these drugs show decreased incidence or delay of brain metastasis. I'd be interested to hear back whether this seems like an approachable problem for OHDSI.
By the way, my PhD is from Columbia University, officially in chemistry, but I studied molecular and structural biology. I loved every minute of it, and I love NYC. If OHDSI provides me with even a shadow of an excuse to visit in person, I will jump at it!