Dear Colleagues,
I would like to propose to start a Maternal Child Health Working group. who is interested to join? Please find description below
Improving the well-being of mothers, infants, and children is an important public health goal across the world. Their well-being determines the health of the next generation and can help predict future public health challenges for families, communities, and the health care system. The Global Research in Pediatric project funded by the European Commission, the International Society for Pharmaco-epidemiology and the FDA demonstrated that there is an urgent need to build research capacity to better exploit the evidence that is being compiled in real life. Especially in these vulnerable groups, which are often excluded from clinical trials and where most drugs are used off label, data generated in routine health care should be utilized. Data should be made actionable and provide evidence that can support mothers, parents and health care providers and public health officials to make better informed decisions. However, there are several methodological challenges that are related to
- Linkage of mothers and their children in health care databases
- Estimation of gestational age and pregnancy in health care databases
- Long-term follow-up of children
- Pregnancy and neonatal outcome phenotyping in health care databases
- Exposure & confounder patterns in children: dose and duration of drugs and co-morbidities
The OHDSI maternal child health group aims to specifically address:
- Methods & validation for mother-child linkage in health care databases
- Designs, methods and implementation of multisite drug utilization studies and vaccine coverage in mothers and children
- Estimation of recurrent/chronic disease incidence and prevalence in children and mothers using health care databases
- Methods and designs for maternal drug/vaccine exposure and pediatric drug/vaccine exposure outcome studies (safety & effectiveness)
The OHDSI MCH group will leverage content expertise from the Global Research in Pediatrics network of Excellence (www.grip-network.org) the ADVANCE project (www.advance-vaccines.eu) and the GAIA project (http://gaia-consortium.net) and bridge with the ISPE Pediatrics Special Interest Group the Vaccine Special Interest Group and the Pregnancy Special Interest Group. Several R programs and tools (ontologies) were developed in GRIP and ADVANCE that might be brought into the community. As this is an application domain in high need of actionable data, it envisions to actively collaborate with various other OHDSI (methods) working groups.
